Methods of preparing cannabinoids or derivatives thereof
AssigneeFloraScience Inc.
InventorsRobert Paul Jensen, Vaughn Hartung
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Abstract
Provided are methods of preparing cannabinoids and cannabinoid derivatives and compositions containing the cannabinoids and derivatives.
Claims30
A method of preparing cannabinol, or a pharmaceutically acceptable salt thereof, the method comprising:
- admixing a catalyst, cannabidiol, and an oxidizing agent to form cannabinol, or a pharmaceutically acceptable salt thereof,
- wherein the catalyst is I2, Br2, or Cl2.
A method of preparing cannabinol, or a pharmaceutically acceptable salt thereof, the method comprising:
- admixing a catalyst, an oxidizing agent, and tetrahydrocannabinol to form cannabinol, or a pharmaceutically acceptable salt thereof,
- wherein the catalyst is I2, Br2, or Cl2.
The method of 24, wherein admixing the catalyst and the cannabidiol is performed at a temperature of about 35° C. to about 200° C., about 50° C. to about 150° C., about 50° C. to about 100° C., or about less than about 100° C.
A method of preparing cannabinol, or a pharmaceutically acceptable salt thereof, the method comprising:
- (a) admixing cannabidiol and a catalyst to form a mixture of Δ(8,9)-tetrahydrocannabinol and Δ(9,10)-tetrahydrocannabinol;
- and
- (b) admixing the mixture and an oxidizing agent to form the cannabinol, or a pharmaceutically acceptable thereof,
- wherein the catalyst is 12 and the 12 is present in an amount of less than about 5 mol %, based on the total mols of the cannabidiol.
A method of preparing acetylcannabinol, or a pharmaceutically acceptable salt thereof, the method comprising:
- admixing cannabidiol, an oxidizing agent, I2, and acetic acid to form a mixture comprising cannabinol, or a pharmaceutically acceptable salt thereof, wherein the 12 is present in an amount of less than about 5 mol %, based on the total mols of cannabidiol;
- and
- admixing the mixture with a dehydrating agent to form acetylcannabinol, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.