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AssigneeNIRvana Sciences Inc.
InventorsJames Bruce Pitner, Rajalekha Manjakuppam Rajamahendiran, Russell D. Thomas
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Provided are photoacoustic imaging contrast agents that include at least one radiation-absorbing component comprising a bacteriochlorin, a metallobacteriochlorin, a derivative thereof, or a combination thereof. Also provided are methods for using the disclosed photoacoustic imaging contrast agents either singly or in combination for generating an image of a volume, optionally a subject or a body part, cell, tissue, or organ thereof. Further provided are compositions and methods for multiplex photoacoustic imaging of a volume, optionally a subject or a body part, cell, tissue, or organ thereof using photoacoustic imaging contrast agents that include a plurality of the presently disclosed bacteriochlorins, metallobacteriochlorins, and/or derivatives thereof simultaneously.
A pharmaceutical composition comprising a photoacoustic imaging contrast agent and a pharmaceutically acceptable carrier, diluent, or excipient, wherein the photoacoustic imaging contrast agent comprises at least one radiation-absorbing component comprising a metallobacteriochlorin with a targeting agent attached thereto, and further wherein the at least one radiation-absorbing component comprises a compound selected from the group consisting of:
A method of generating an image of a volume, the method comprising:
A method for multiplex photoacoustic imaging of a volume, the method comprising:
Dependencies are inferred from the claim text.