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US 12,042,385 B2Granted
Compositions and methods for treating bone fractures
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsHamid Saadatmanesh, Mehrnoosh Zarkoob
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Abstract
Provided herein are compositions and methods for treating bone fractures. In particular, provided herein are systems comprising carbon fiber sleeves and biocompatible polymers and the use of such systems in treating or preventing bone fractures.
Claims9
A method of treating, stabilizing, or preventing a bone fracture or strengthening a bone, comprising:
- a. making at least a first hole and a second hole through said bone by drilling or laparoscopy;
- wherein a first of said holes is placed on a proximal side of said bone fracture and a second of said holes is on a distal side of said bone fracture;
- b. inserting a fiber tube in said first hole, wherein said inserting said fiber tube comprises the steps of:
- i. inserting said fiber tube in said first of said holes, and
- ii. drawing said fiber tube via a lead wire that exits said second of said holes;
- wherein said fiber tube is placed between said first and second holes;
- wherein said fiber tube comprises one or more surface modifications selected from the group consisting of electrochemical, chemical, thermal, discharge plasma, and radiation treatment;
- wherein said fiber tube is pre-impregnated with a resin system at a temperature below the physiological temperature and resin system polymerizes at physiological temperature after insertion of said fiber tube in said bone;
- wherein said fiber tube is removable;
- wherein said fiber tube is configured to resist compressive, torsional, and shear forces when placed in a bone, conforms to the shape of a bone cavity in said bone, and is configured to retain tube shape after placement in said bone;
- and
- c. filling said fiber tube, said first hole, and said second hole with a biocompatible polymer;
- wherein said biocompatible polymer is pre-compressed before filling, is an expansive polymer, and comprises a carbon fiber reinforcing component;
- wherein said fiber tube and said biocompatible polymer further comprises one or more active agents selected from the group consisting of a drug, antimicrobial agent, antibiotic, bone healing promoting agent, chemotherapeutic agent, or bone precursor such as osteoblast or osteoclast;
- wherein at least one physical property of said biocompatible polymer is altered by an external stimulus that is either electrical or thermal energy;
- wherein said first hole and said second hole act as shear keys after being filled with the biocompatible polymer.
13 more elements
Dependencies are inferred from the claim text.