Technetium-99M generator for enriched molybdenum

A method for separating a parent isotope from a daughter isotope, the method comprising:

• a) supplying irradiated target material;
• b) dissolving the irradiated target material to form an aqueous solution of molybdate salt;
• c) treating the dissolved irradiated target with ethanol to form a first solid phase of the parent isotope and a first liquid phase of the daughter isotope;
• d) filtering the first liquid phase of the daughter isotope with a guard column to capture residual target material that was not precipitated;
• e) capturing the daughter isotope contained in the filtered first liquid phase onto a concentration column;
• f) eluting the captured daughter isotope in a low-volume, pharmaceutically suitable matrix;
• g) dissolving the first solid phase of parent isotope in water, and;
• h) repeating steps c-g wherein the parent isotope is an element selected from the group consisting of molybdenum, tungsten, and combinations thereof and daughter isotope is an element selected from the group consisting of technetium, rhenium, and combinations thereof.