Short DNA aptamers and methods for promoting remyelination
AssigneeMayo Foundation for Medical Education and Research
InventorsBrandon A. Wilbanks, John A. Smestad, Moses Rodriguez, Louis J. Maher, III
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Abstract
Materials and methods related to using short DNA aptamers to treat demyelinating diseases are provided herein.
Claims16
A composition comprising a pharmaceutically acceptable carrier and a nucleic acid aptamer comprising the sequence set forth in any one of SEQ ID NOS:6 to 19, a fragment of any one of SEQ ID NOS:6 to 19, or a variant sequence having at least 90% identity to the sequences of any one of SEQ ID NOS:5 to 19.
A method for treating a mammal identified as having a demyelinating disease, wherein the method comprises administering a nucleic acid aptamer to the mammal, and wherein the nucleic acid aptamer comprises the sequence set forth in any one of SEQ ID NOS:6 to 19, a fragment of any one of SEQ ID NOS:6 to 19, or a variant sequence having at least 90% identity to the sequences of any one of SEQ ID NOS:5 to 19.
A method for promoting neuronal remyelination in a mammal in need thereof, comprising administering to the mammal a pharmaceutical composition comprising a nucleic acid aptamer in an amount effective to promote remyelination, wherein the nucleic acid aptamer comprises the sequence set forth in any one of SEQ ID NOS:6 to 19, a fragment of the sequence set forth in any one of SEQ ID NOS:6 to 19, or a variant sequence having at least 90% identity to the sequence of any one of SEQ ID NOS:5 to 19.
Dependencies are inferred from the claim text.