DNA-peptide composite comprising high-density functional group, DNA-peptide-nanomaterial composite and preparation method therefor, and DNA-metal nanowire and manufacturing method therefor

A method for producing a DNA-metal nanowire, the method comprising:

• binding a double-stranded DNA molecule with a peptide comprising at least one functional group to form a DNA-peptide complex having a high-density functional group, wherein the peptide contains an amino acid sequence capable of binding to the DNA molecule and the at least one functional group at a terminal thereof;
• and the at least one functional group comprises at least one selected from a group consisting of a thiol group (—SH), azide, alkyne, and a combination thereof, and
• wherein the amino acid sequence comprises lysine (K) and tryptophan (W);
• forming a covalent bond between the at least one functional group and a metal nanoparticle to produce a DNA-peptide-metal nanoparticle complex;
• immersing the DNA-peptide-metal nanoparticle complex in a metal growth solution containing a reducing agent;
• and
• removing the metal growth solution.

A method for producing a DNA-peptide-nanoparticle complex, the method comprising:

• binding a peptide to a double-stranded DNA molecule to obtain a DNA-peptide complex,
• wherein the peptide comprises an amino acid sequence capable of binding to the DNA molecule via at least one of electrostatic interaction, intercalation or groove binding, and the peptide comprises the at least one functional group,
• wherein the at least one functional group comprises at least one selected from a group consisting of a thiol group (—SH), azide, alkyne, and a combination thereof, and
• wherein the amino acid sequence comprises lysine (K) and tryptophan (W) and does not include glutamate (E);
• and
• forming a covalent bond between a metal nanoparticle and the at least one functional group of the peptide in the DNA-peptide complex to obtain a DNA-peptide-nanoparticle complex in which the peptide acts as a linker by linking the metal nanoparticle to the DNA molecule.