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US 12,037,560 B2Granted
UV cure topcoatings for medical devices
AssigneeBiocoat Incorporated
InventorsTyler Richard Long, Casmir S. Ilenda
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Abstract
The invention concerns coating compositions for medical devices or medical implants comprising a polymer which is soluble in water or water-alcohol solutions, the polymer made from monomers comprising: (a) at least one monomer that is a photo radical generator, and (b) at least one monomer comprising one or both of (i) ethylenic monomers comprising at least one acidic group and (ii) one or more of acrylates or acrylamides; wherein the molar ratio of one or both of (i) ethylenic monomers comprising at least one acidic group and (ii) one or more of acrylates or acrylamides to photo radical generator group is 20:1 to 500:1.
Claims19
A coating composition for medical devices or medical implants comprising a random polymer which is soluble in water or water-alcohol solutions, the polymer made from monomers consisting essentially of:
- (a) at least one monomer that is a photo radical generator comprising one or more of 4-methacryloxy-2-hydroxybenzophenone, 4-acryloxybenzophenone, 4-methacryloxybenzophenone, acrylamidobenzophenone, methacrylamidobenzophenone, 2-hydroxy-4-acryloxyethoxybenzophenone, and 2-hydroxy-4-methacryloxyethoxybenzophenone, and
- (b) (i) at least one monomer comprising ethylenic monomers comprising at least one acidic group;
- and (ii) at least one monomer comprising one or more of acrylates or acrylamides, provided one monomer is N-(2-hydroxyethyl)acrylamide;
- wherein the ethylenic monomers comprise acrylic acid;
- wherein the acrylates or acrylamides comprise acrylamide, N-(2-hydroxyethyl)acrylamide, 2-hydroxyethyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxypropyl methacrylate, and N-(2-hydroxyethyl) methacrylamide, N-acryloylamido-ethoxyethanol, N-(hydroxymethyl) acrylamide, N-[tris(hydroxymethyl)methyl]acrylamide, 4-hydroxybutyl acrylate, hydroxypropyl acrylate, methyl 3-hydroxy-2-methylenebutyrate, hydroxypropyl methacrylate, 2-allyloxyethanol, 3-allyloxy-1,2-propanediol, 1,4-butanediol vinyl ether, di(ethylene glycol)vinyl ether, ethylene glycol vinyl ether, N,N-1,2-dihydroxyethylene-bis-acrylamide, N,N-1,2-dihydroxyethylene-bis-methyacrylamide, N-hydroxymethyl methacrylamide, N-tri(hydroxymethyl)-methyl-methacrylamide, or any mixture of the foregoing;
- wherein the molar ratio of both of (i) ethylenic monomers comprising at least one acidic group and (ii) one or more of acrylates or acrylamides to (a) monomers comprising a photo radical generator is 20:1 to 500:1.
3 more elements
A coating composition for medical devices or medical implants comprising a random polymer which is soluble in water or water-alcohol solutions, the polymer made from monomers consisting essentially of:
- (a) at least one monomer that is a photo radical generator comprising one or more of 4-methacryloxy-2-hydroxybenzophenone, 4-acryloxybenzophenone, 4-methacryloxybenzophenone, acrylamidobenzophenone, methacrylamidobenzophenone, 2-hydroxy-4-acryloxyethoxybenzophenone, and 2-hydroxy-4-methacryloxyethoxybenzophenone, and
- (b) (i) at least one monomer comprising ethylenic monomers comprising at least one acidic group;
- and (ii) at least one monomer comprising one or more of acrylates or acrylamides;
- wherein the ethylenic monomers comprising at least one acidic group comprises acrylic acid, methacrylic acid, 2-ethylacrylic acid, 2-propylacrylic acid, acryloxypropionic acid, isocrotonic acid, maleic anhydride, maleic acid and half esters, half amides and half thioesters of maleic acid, fumaric acid and itaconic acid, and mixtures thereof;
- wherein the acrylates or acrylamides comprise acrylamide, N-(2-hydroxyethyl)acrylamide, 2-hydroxyethyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxypropyl methacrylate, and N-(2-hydroxyethyl) methacrylamide, N-acryloylamido ethoxyethanol, N-(hydroxymethyl) acrylamide, N-[tris(hydroxymethyl)methyl]acrylamide, 4-hydroxybutyl acrylate, hydroxypropyl acrylate, methyl 3-hydroxy-2-methylenebutyrate, hydroxypropyl methacrylate, 2-allyloxyethanol, 3-allyloxy-1,2-propanediol, 1,4-butanediol vinyl ether, di(ethylene glycol)vinyl ether, ethylene glycol vinyl ether, N,N-1,2-dihydroxyethylene-bis-acrylamide, N,N-1,2-dihydroxyethylene-bis-methyacrylamide, N-hydroxymethyl methacrylamide, N-tri(hydroxymethyl)-methyl-methacrylamide, or any mixture of the foregoing;
- wherein the molar ratio of both of (i) ethylenic monomers comprising at least one acidic group and (ii) one or more of acrylates or acrylamides to (a) monomers comprising a photo radical generator is 20:1 to 500:1;
- wherein the polymer has a weight-average molecular weight (Mw) of between 20,000 and 800,000.
4 more elements
A coating composition for medical devices or medical implants comprising a random polymer which is soluble in water or water-alcohol solutions, the polymer made from monomers consisting essentially of:
- (a) at least one monomer that is a photo radical generator comprising one or more of 4-methacryloxy-2-hydroxybenzophenone, 4-acryloxybenzophenone, 4-methacryloxybenzophenone, acrylamidobenzophenone, methacrylamidobenzophenone, 2-hydroxy-4-acryloxyethoxybenzophenone, and 2-hydroxy-4-methacryloxyethoxybenzophenone, and
- (b) (i) at least one monomer comprising ethylenic monomers comprising at least one acidic group;
- and (ii) at least one monomer comprising one or more of acrylates or acrylamides;
- wherein the ethylenic monomers comprising at least one acidic group comprises acrylic acid, methacrylic acid, 2-ethylacrylic acid, 2-propylacrylic acid, acryloxypropionic acid, isocrotonic acid, maleic anhydride, maleic acid and half esters, half amides and half thioesters of maleic acid, fumaric acid and itaconic acid, and mixtures thereof;
- wherein the acrylates or acrylamides comprise acrylamide, N-(2-hydroxyethyl)acrylamide, 2-hydroxyethyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxypropyl methacrylate, and N-(2-hydroxyethyl) methacrylamide, N-acryloylamido-ethoxyethanol, N-(hydroxymethyl) acrylamide, N-[tris(hydroxymethyl)methyl]acrylamide, 4-hydroxybutyl acrylate, hydroxypropyl acrylate, methyl 3-hydroxy-2-methylenebutyrate, hydroxypropyl methacrylate, 2-allyloxyethanol, 3-allyloxy-1,2-propanediol, 1,4-butanediol vinyl ether, di(ethylene glycol)vinyl ether, ethylene glycol vinyl ether, N,N-1,2-dihydroxyethylene-bis-acrylamide, N,N-1,2-dihydroxyethylene-bis-methyacrylamide, N-hydroxymethyl methacrylamide, N-tri(hydroxymethyl)-methyl-methacrylamide, or any mixture of the foregoing;
- wherein the molar ratio of both of (i) ethylenic monomers comprising at least one acidic group and (ii) one or more of acrylates or acrylamides to (a) monomers comprising a photo radical generator is 20:1 to 500:1;
- additionally comprising a second polymer which is soluble in water or water-alcohol solutions;
- wherein the second polymer has a weight-average molecular weight (Mw) of between 50,000 and 800,000.
5 more elements
Dependencies are inferred from the claim text.