Methods for treating multidrug resistant breast cancer
AssigneeThe Hong Kong Polytechnic University
InventorsMing-Cheung Larry Chow, Kit Ying Choy, Chin Fung Chan, Lai King Wong
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Abstract
The present disclosure provides methods and composition for treating multi-drug resistant cancers, in particular, breast cancers, via administration to a subject the composition including a peptide having a sequence complementary to a highly conserved motif present in substantially all integrins responsible for an integrin-mediated attachment-independent chemoresistance to one or more chemotherapeutic agents. The binding of the sequence of the peptide to the highly conserved motif will enhance accumulation of the chemotherapeutic agents in the tumor-initiating cells and in turn restores the function of the chemotherapeutic agents in the tumor-initiating cells.
Claims14
A composition comprising a peptide, the peptide comprising a TAT peptide represented by SEQ ID NO:1 and a Shank-associated RH domain-interacting protein (SHARPIN) represented by SEQ ID NO:2;
- or a retro-inverso peptide thereof, wherein the TAT peptide is directly bound to the SHARPIN peptide (SP).
Dependencies are inferred from the claim text.