Triterpene saponin analogues
AssigneesAdjuvance Technologies, Inc., Memorial Sloan Kettering Cancer Center
InventorsDavid Y. Gin, Eric Chea, Alberto Fernandez-Tejada, Jeffrey Gardner, Jason Lewis, Philip Livingston, J. Tyler Martin, Lars Nordstroem, Naga Vara Kishore Pillarsetty, Govind Ragupathi, Derek Tan
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Abstract
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.
Claims20
A compound having the formula
- wherein (a) R1 is —CH3, and R2 is —OH or —H, or (b) R1 is —CHO or —CH3, and R2 is —H,
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound of the formula
- wherein (a) R1 is —CH3, and R2 is —OH or —H, or (b) R1 is —CHO or —CH3, and R2 is —H, or a pharmaceutically acceptable salt thereof;
- and
- an immunologically effective amount of an antigen.
A method of conferring resistance to an infection, the method comprising administering an antigen in combination with a pharmaceutical composition comprising a compound of the formula
- wherein (a) R1 is —CH3, and R2 is —OH or —H, or (b) R1 is —CHO or —CH3, and R2 is —H, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.