Pre-assembled, protected, chemically stable, chemoselective linkers
AssigneeCowper Sciences Inc.
InventorsPatrick Walsh, David Smith, Gaurav Saini, Jae H. Park
Life of this patent
Estimating the term…
Abstract
Molecules compounds are provided having the structure in Formula I, or a salt thereof, wherein n1 is independently 0, 1, 2, or 3; n2 is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20; n3 is from 0, 1, 2, or 3; n4 is 0 or 1; and n5 is 0, 1, 2, or 3; and wherein X is O, N, or S; Y, Z, XX, and YY are the same or different and are independently O or S; ZZ comprises nitrogen, oxygen, sulfur, or selenium; and wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 are as described herein. Methods are also provided for the synthesis of and use of the provided molecules in applications for diagnostic testing.
Claims23
A molecule having the structure:
- or a salt thereof,
- wherein n1=1-15 and n2=1-6;
- and
- wherein R1 and R2 are the same or different and are independently hydrogen or acyloxy;
- R3 is alkyl, alkenyl, alkynyl or aryl, all optionally substituted with 1, 2, 3, or 4 groups selected from hydrogen, halo, alkyl, polyhaloalkyl, alkyoxy, haloalkoxy, polyhaloalkoxy, alkoxycarbonyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, hydroxyl, hydroxyalkyl, nitro, cyano, amino, substituted amino, alkylamino, dialkylamino, thiol, alkylthio, alkylcarbonyl, acyl, alkoxycarbonyl, aminocarbonyl, alkylsulfinyl, sulfonamide, or sulfonyl;
- and
- R4, R5, and R6 are the same or different and are independently selected from hydrogen, alkyl, silyl, or siloxy.
Dependencies are inferred from the claim text.