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AssigneeZhejiang Jinyishengshi Bioengineering Co., Ltd.
InventorsFulin Hu, Shiping Yuan, Jinpei Song, Wei Han
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The present invention provides a disposable bioprocess bag, a manufacturing method therefor and a hot-melt annular welding machine, relating to the technical field of biopharmaceutics. The manufacturing method comprises: preparing a first cropping template to a fourth cropping template according to a top, an upper portion, a lower portion and a bottom of a bioreactor; cropping a raw material film according to the first cropping template to the fourth cropping template to obtain a first membrane material to a fourth membrane material, wherein the fourth membrane material directly serves as a rounded bottom; welding at least two pockets on the first membrane material to obtain a rounded top; welding the second membrane material to obtain a cylindrical upper portion; welding the third membrane material to obtain a lower portion in the shape of an inverted rounded truncated cone; and welding, using a hot-melt annular welding machine, the rounded top, the cylindrical upper part, the lower portion in the shape of an inverted rounded truncated cone and the rounded bottom, to obtain a disposable bioprocess bag. According to the present invention, the physical properties of the welded edge of the disposable bioprocess bag are improved, and the fit of the disposable bioprocess bag to the bioreactor are also enhanced.
A manufacturing method of a single-use bioprocessing bag, wherein the single-use bioprocessing bag is used to be placed in a bioreactor, with an upper top of the bioreactor being circular, an upper part of the bioreactor being cylindrical, a lower part of the bioreactor being inverted truncated cone shape, and a lower bottom of the bioreactor being circular, the single-use bioprocessing bag comprises a circular upper top, a cylindrical upper part, a lower part of an inverted truncated cone, and a circular lower bottom, with the circular upper top having at least two bag openings;
A hot-melt ring welding machine, comprising a base, a support, an upper mold, a lower mold, a cylinder, and a screw guide rail, wherein the lower mold is detachably connected to the base, the support is fixed to one end of the base, the screw guide rail is fixed on the support, the cylinder is fixed on the screw guide rail, the upper mold is detachably connected to the bottom of the piston of the cylinder, the upper mold is of an arc-shaped piece, the lower mold is a hollow cylinder, the upper mold has a built-in heating module, and the lower mold is able to rotate about its axial direction at any angle between 0 and 360°.
A manufacturing method of a single-use bioprocessing bag, wherein the single-use bioprocessing bag is used to be placed in a bioreactor, with an upper top of the bioreactor being circular, an upper part of the bioreactor being cylindrical, a lower part of the bioreactor being inverted truncated cone shape, and a lower bottom of the bioreactor being circular, the single-use bioprocessing bag comprises a circular upper top, a cylindrical upper part, a lower part of an inverted truncated cone, and a circular lower bottom, with the circular upper top having at least two bag openings;
Dependencies are inferred from the claim text.