Edible plant-derived nanoparticles for regulation of gut microbiota
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorHuang-Ge Zhang
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Abstract
Provided are methods for modulating gut microbiota in subjects. In some embodiments, the methods include administering to a subject an effective amount of a composition that includes a first edible plant-derived nanoparticle encapsulating an effective amount of RNA. Also provided are methods for preventing and/or treating gut dysbiosis, methods for modulating bacterial growth, methods for modulating inflammatory cytokines, methods for reducing migration of bacterial from the gut to gut-associated bloodstream, and compositions for use in the presently disclosed methods, including pharmaceutical compositions.
Claims5
A method for modulating gut microbiota, the method comprising administering to a subject an effective amount of a composition comprising a first edible plant-derived nanoparticle encapsulating an effective amount of an miRNA selected from the group consisting of miR166c, miRNA167a, miR319a, miR396e, miR842, and miR827, optionally wherein the miRNA is obtained from a second edible-plant derived nanoparticle, wherein the effective amount results in a change in the makeup of the subject's gut microbiota relative to that present prior to the administering step.
Dependencies are inferred from the claim text.