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US 12,036,247 B2Granted
Multiple transgene recombinant adenovirus
AssigneeEpicentRx, Inc.
InventorsTony R. Reid, Christopher Larson, Bryan T. Oronsky
Life of this patent
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Abstract
The invention relates to a recombinant adenovirus comprising two or more therapeutic transgenes, e.g., two components of a heterodimeric cytokine, separated by a cleavable linker.
Claims13
An oncolytic adenovirus comprising
- a first nucleotide sequence encoding a first therapeutic transgene,
- a second nucleotide sequence encoding a second therapeutic transgene, and
- a third nucleotide sequence encoding a proteolytic cleavage site comprising a furin cleavage site disposed between the first nucleotide sequence and the second nucleotide sequence,
- wherein the first nucleotide sequence, the third nucleotide sequence, and the second nucleotide sequence comprise SEQ ID NOs:
- 8 or 9.
2 more elements
Dependencies are inferred from the claim text.