Combination of a ubiquitin-conjugating enzyme complex inhibitor and antihypertensive and/or hypoglycemic drugs in diabetic kidney disease
AssigneeUniversita' Degli Studi Di Bari Aldo Moro
InventorsLoreto Gesualdo, Paola Pontrelli
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Abstract
The present invention relates to a composition comprising at least one inhibitor of the enzymatic complex conjugating ubiquitin Ubc13/Uev1a and at least one anti-hypertensive agent inhibiting the renin-angiotensin-aldosterone system and/or a hypoglycemic agent. Medical uses and pharmaceutical compositions comprising this composition also fall within the scope of the present invention. In particular, this composition can be used for the treatment or prevention of the renal fibrotic damage, in particular in patients suffering from diabetes.
Claims19
A method for treating or preventing the progression of renal fibrosis comprising administration to an individual in need thereof a pharmaceutical composition of comprising:
- (a) at least one inhibitor of a ubiquitin conjugating enzymatic complex Ubc13/Uev1a comprising 2-(4-methylphenyl) sulfonyl-5-nitrofuran;
- and
- (b) at least one antihypertensive agent inhibiting the renin-angiotensin-aldosterone system comprising ramipril.
A method for treating or preventing the progression of diabetic nephropathy comprising administration to an individual in need thereof a pharmaceutical composition comprising:
- (a) at least one inhibitor of a ubiquitin conjugating enzymatic complex Ubc13/Uev1a comprising 2-(4-methylphenyl) sulfonyl-5-nitrofuran;
- and
- (b) at least one antihypertensive agent inhibiting the renin-angiotensin-aldosterone system comprising ramipril.
A method for treating or preventing the progression of renal fibrosis comprising administration to an individual in need thereof:
- (a) at least one inhibitor of a ubiquitin conjugating enzymatic complex Ubc13/Uev1a comprising 2-(4-methylphenyl) sulfonyl-5-nitrofuran;
- and
- (b) at least one antihypertensive agent inhibiting the renin-angiotensin-aldosterone system comprising ramipril.
A method for treating or preventing the progression of diabetic nephropathy comprising administration to an individual in need thereof:
- (a) at least one inhibitor of a ubiquitin conjugating enzymatic complex Ubc13/Uev1a comprising 2-(4-methylphenyl) sulfonyl-5-nitrofuran;
- and
- (b) at least one antihypertensive agent inhibiting the renin-angiotensin-aldosterone system comprising ramipril.
A method for treating, preventing, or preventing the progression of renal fibrosis comprising administration to an individual in need thereof:
- (a) at least one inhibitor of a ubiquitin conjugating enzymatic complex Ubc13/Uev1a comprising 2-(4-methylphenyl) sulfonyl-5-nitrofuran;
- and
- (b) at least one hypoglycemic agent comprising empagliflozin.
A method for treating, preventing, or preventing the progression of diabetic nephropathy comprising administration to an individual in need thereof:
- (a) at least one inhibitor of a ubiquitin conjugating enzymatic complex Ubc13/Uev1a comprising 2-(4-methylphenyl) sulfonyl-5-nitrofuran;
- and
- (b) at least one hypoglycemic agent comprising empagliflozin.
Dependencies are inferred from the claim text.