Co-crystals of NURR1-lbd in complex with a cyclopentenone prostaglandin and modulators of NURR1
AssigneeNanyang Technological University
InventorsHo Sup Yoon, Sreekanth Rajan, Hui Ting Toh, Xuewei Liu, Hui Yao
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Abstract
Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.
Claims3
A method of modulating a Nurr1, the method comprising contacting the Nurr1 with an effective amount of a cyclopentenone prostaglandin derivative, wherein the cyclopentenone prostaglandin derivative YH279:
Dependencies are inferred from the claim text.