Polymeric biomaterials derived from phenolic monomers and their medical uses
AssigneeRutgers, The State University of New Jersey
InventorsJoachim B. Kohn, Durgadas Bolikal
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Abstract
The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
Claims10
A diphenol compound of formula:
- wherein:
- y1 and y2 are each independently 0, 1, 2, 3 or 4;
- m and n are each independently an integer in the range of 1 to 12;
- X1 and X2, at each occurrence, are each independently bromine (Br) or iodine (I);
- L1 is selected from the group consisting of a bond, oxygen (—O—);
- and
- L4 is selected from the group consisting of a bond, oxygen (—O—), and optionally substituted phenoxy of formula —C6H4—O—;
- wherein n is not 2;
- and
- wherein when both L1 and L4=bond, then at least one of y1 or y2 is non-zero.
Dependencies are inferred from the claim text.