Variant IgG Fc polypeptides and uses thereof
AssigneeSeismic Therapeutic, Inc.
InventorsYen-Lin Chen, Ryan Peckner, Nathan Higginson-Scott, Daniela Cipolletta, Yanfeng Zhou, Kevin Lewis Otipoby, Jyothsna Visweswaraiah
Life of this patent
Estimating the term…
Abstract
Embodiments provided herein, provide for variant IgG Fc polypeptides, dimeric molecules, pharmaceutical compositions, and methods that can be used to target at cells to modulate the activity of the same to treat disorders, such as autoimmune disorders or cancers.
Claims30
An Fc polypeptide having at least 95% identity to an amino acid sequence comprising the amino acid sequence of SEQ ID NO:
- 88 provided that the Fc polypeptide comprises:
- a glutamic acid residue at position 237 and a glutamic acid residue at position 238, wherein the positions are according to EU numbering;
- an aspartic acid residue at position 237, a glycine residue at position 238, an alanine residue at position 240, an aspartic acid residue at position 269, a glutamic acid residue at position 270, and an arginine residue at position 330, wherein the positions are according to EU numbering;
- or
- a phenylalanine residue at position 234, a glutamic acid residue at position 235, an aspartic acid residue at position 268, a glycine residue at position 271, and an alanine residue at position 329, wherein the positions are according to EU numbering.
An Fc polypeptide having at least 95% identity to an amino acid sequence comprising the amino acid sequence of SEQ ID NO:
- 88 provided that the Fc polypeptide comprises a glutamic acid residue at position 237 and a glutamic acid residue at position 238, wherein the positions are according to EU numbering.
An Fc polypeptide having at least 95% identity to an amino acid sequence comprising the amino acid sequence of SEQ ID NO:
- 88 provided that the Fc polypeptide comprises an aspartic acid residue at position 237, a glycine residue at position 238, an alanine residue at position 240, an aspartic acid residue at position 269, a glutamic acid residue at position 270, and an arginine residue at position 330, wherein the positions are according to EU numbering.
An Fc polypeptide having at least 95% identity to an amino acid sequence comprising the amino acid sequence of SEQ ID NO:
- 88 provided that the Fc polypeptide comprises a phenylalanine residue at position 234, a glutamic acid residue at position 235, an aspartic acid residue at position 268, a glycine residue at position 271, and an alanine residue at position 329, wherein the positions are according to EU numbering.
Dependencies are inferred from the claim text.