Photoresponsive protein and utilization thereof
AssigneeNagoya Institute of Technology
InventorsShunta Shigemura, Shoko Hososhima, Satoshi Tsunoda, Hideki Kandori
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Abstract
An excellent photosensitivity is exhibited by a protein including, at a position or positions corresponding to one or two or more positions selected from the group made of the following (1) to (3) in a first amino acid sequence represented by SEQ ID NO: 1: (1) positions 39, 94, 98, 102, 110, 113, 114, 162, 224, 225, 230, 231, and 235, (2) positions 53, 61, 68, 74, 76, 80, 130, 137, 194, 195, 198, 200, 204, 205, 209, 210, 253, and 254, and (3) positions 46, 83, 84, 87, 90, 91, 116, 117, 120, 124, 139, 142, 143, 146, 173, 214, 216, 217, 238, 242, and 245, an amino acid residue different from that in the first amino acid sequence, and that has channel activity.
Claims6
A protein composed of the amino acid sequence represented by SEQ ID NO:
- 1 with one or more mutations and having channel activity, wherein:
- the one or more mutations comprise one or more amino acid substitutions selected from the group consisting of L53A, L53N, E76Q, V83A, V83T, A87S, K137A, L146A, K198A, K204A, G216S, S230E, and Q231L and optionally further comprise a deletion, substitution, or insertion of one or two amino acid residues, and
- the amino acid sequence of the protein has 90% or more identity with the amino acid sequence represented by SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.