Prostaglandin E synthase inhibitors and methods for utilizing the same
AssigneeUniversity of Kentucky Research Foundation
InventorsChang-Guo Zhan, Fang Zheng, Kai Ding, Ziyuan Zhou
Life of this patent
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Abstract
Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.
Claims10
A compound of the formula:
- or pharmaceutically acceptable salts thereof,
- wherein R1 is selected from the group consisting of H, an alkyl, an alkyl halide, an ether, and a carboxylic acid;
- wherein R2 is selected from the group consisting of an alkyne and an aromatic;
- and
- wherein R3 is selected from the group consisting of H, a carboxyl, a carboxylic acid, and an alkyl.
A compound having the formula selected from the group consisting of:
A pharmaceutical composition, comprising:
- a first compound of the formula
- or pharmaceutically acceptable salts thereof,
- wherein R1 is selected from the group consisting of H, an alkyl, an alkyl halide, an ether, and a carboxylic acid,
- wherein R2 is selected from the group consisting of H, a halide, an alkyne, and an aromatic, and
- wherein R3 is selected from the group consisting of H, a carboxyl, a carboxylic acid, and an alkyl;
- a pharmaceutically-acceptable carrier;
- and
- a second compound or composition having mPGES-1 inhibition activity, having anti-inflammatory activity, being useful for treatment of an inflammation disorder, being useful for treatment of symptoms associated with inflammation and/or an inflammation disorder, or combinations thereof.
Dependencies are inferred from the claim text.