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US 12,030,864 B2Granted
Small molecule anticancer agents, combinations and uses thereof
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsBrian Keith Law, Ronald K. Castellano
Life of this patent
Estimating the term…
Abstract
The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.
Claims14
A compound of Formula III, or salt thereof:
- wherein, X is S or Se;
- Y is S or Se;
- R3 is selected from H or C1-C6 alkoxy;
- R4 is selected from H or C1-C6 alkoxy;
- n is 0, 1, 2, or 3;
- o is 0, 1, 2, or 3;
- and
- denotes a carbon-carbon single bond or double bond;
- wherein if is a single bond, X and Y are both S, and n and o are each 1, then at least one of R3 or R4 is C1-C6 alkoxy.
6 more elements
A compound, wherein the compound is:
- 1,2-diselenane-1,1-dioxide;
- 3,6-dihydro-1,2-dithiine-1,1-dioxide;
- trans-1,2-dithiane-4,5-diol-1,1-dioxide;
- trans-1,2-dithiane-4,5-diamino-1,1-dioxide;
- trans-1,2-dithiane-4,5-diazido-1,1-dioxide;
- cis-1,2-dithiane-4,5-diol-1,1-dioxide;
- cis-1,2-dithiane-4,5-diamino-1,1-dioxide;
- cis-1,2-dithiane-4,5-diazido-1,1-dioxide;
- 1,2-dithiane-4,5-dione-1,1-dioxide;
- 1,2-dithiane-(4R,5S-diacetoxy)-1,1-dioxide;
- 1,2-dithiane-(4S,5R-diacetoxy)-1,1-dioxide;
- 1,2-dithiane-(4R,5R-diacetoxy)-1,1-dioxide;
- 1,2-dithiane-(4S,5S-diacetoxy)-1,1-dioxide;
- 1,2-dithiane-(4R,5S-dihydroxy)-1,1-dioxide;
- 1,2-dithiane-(4S,5R-dihydroxy)-1,1-dioxide;
- 1,2-dithiane-(4R,5R-dihydroxy)-1,1-dioxide;
- 1,2-dithiane-(4S,5S-dihydroxy)-1,1-dioxide;
- 1,2-dithiane-4-amino-1,1-dioxide;
- 1,2-dithiane-4-azido-1,1-dioxide;
- 1,2-dithiane-5-amino-1,1-dioxide;
- 1,2-dithiane-5-azido-1,1-dioxide;
- or a salt thereof.
19 more elements
A compound that is
- or salt thereof.
Dependencies are inferred from the claim text.