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US 12,030,858 B2Granted
PARP inhibitors for treating cancer and asthma
AssigneeOregon Health & Science University
InventorsMichael Cohen, Ilsa Kirby
Life of this patent
Estimating the term…
Abstract
Provided are substituted 8-methylquinazolin-4(3H)-one compounds useful as PARP inhibitors for the treatment of cancer and asthma, as well as pharmaceutical compositions comprising them and methods for their synthesis.
Claims19
A compound of Formula I, or a pharmaceutically acceptable salt thereof:
- wherein R1 is selected from C1-C3 alkyl, C2-C3 alkenyl, and C2-C3 alkynyl;
- and
- R2 is selected from a phenyl ring and a 3-membered to 10-membered aromatic, partially unsaturated, or unsaturated heterocycle containing 1, 2, 3, or 4 ring nitrogen atoms, with the phenyl ring and the 5- to 10-membered aromatic, partially unsaturated, or unsaturated heterocycle being substituted by 0, 1, 2 or 3 substituents selected from the group of Cl, F, Br, I, OH, C1-C6 alkyl, —O-C1-C6 alkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —CO2H, —CO2(C1-C6 alkyl), —CO2-phenyl, and —CO2-benzyl;
- wherein the phenyl and benzyl rings of the R2 —CO2-phenyl, —CO2-benzyl groups are substituted by 0, 1, 2, or 3 substituents selected from the group of Cl, F, Br, I, OH, C1-C6 alkyl, —O-C1-C6 alkyl, —NH2, —NH(C1-C6 alkyl), and —N(C1-C6 alkyl)2.
1 more element
Dependencies are inferred from the claim text.