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US 12,023,603 B2Granted
Two-electrode configuration for separations based on electrosorption in electrochemically modulated liquid chromatography (EMLC)
AssigneeUniversity of Utah Research Foundation
InventorsMarc David Porter, Robert Joseph Soto, Mark Andrew Hayes
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Abstract
This invention discloses a design a capillary column for use with electrochemically modulated liquid chromatography (EMLC). The capillary design, which results in a marked reduction in the flow of current through the column, enables the use of a two-electrode column construction that overcomes the mechanical and electrical shortfalls of the conventional standard bore design.
Claims12
An electrochemically modulated liquid chromatography (EMLC) column for separation of a sample, the EMLC column comprising:
- a conductive stationary phase packed in a capillary fluidic channel wherein the stationary phase functions as a working electrode in an electrochemical cell;
- a pseudo-reference electrode housing containing a dual-purpose reference or pseudo reference electrode which is current-carrying and which provides a stable reference potential that is not substantially perturbed by background current of the working electrode, wherein the EMLC column does not include a current-carrying counter electrode other than the dual-purpose reference or pseudo reference electrode;
- and
- a flow splitter connected to the capillary fluidic channel and to the pseudo-reference electrode housing to split a flow of liquid to the capillary fluidic channel and the pseudo-reference electrode housing.
1 more element
Dependencies are inferred from the claim text.