Prokaryotic collagen therapeutics for postoperative adhesions
AssigneesECM Technologies, The Texas A&M University System
InventorsBrooke Russell, Magnus Hook, David McQuillan
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Abstract
The present invention includes a synthetic collagen that facilitates adhesion prevention and methods of use thereof. The present invention includes a prokaryotic collagen that facilitates adhesion prevention and treatment and methods of use thereof. The prokaryotic collagen includes an isolated and purified triple helical backbone protein that facilitates adhesion prevention: one or more alteration in a triple helical backbone protein sequence, and one or more binding motifs, wherein the isolated and purified triple helical backbone protein facilitates adhesion prevention.
Claims6
A method of reducing or eliminating tissue adhesion or fibrosis comprising the steps of:
- providing a non-thrombogenic collagen fusion protein comprising the sequence of SEQ ID NO:
- 7 that facilitates reducing or eliminating tissue adhesion or fibrosis in a biocompatible carrier, and
- applying the non-thrombogenic collagen fusion protein comprising the sequence of SEQ ID NO:
- 7 in a biocompatible carrier to a damaged area for reducing or eliminating tissue adhesion or fibrosis.
Dependencies are inferred from the claim text.