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US 12,023,416 B2Granted
Collagen fibers and articles formed therefrom
AssigneeEdwards Lifesciences Corporation
InventorTara J. Tod
Life of this patent
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Abstract
Methods of manufacturing collagen fibers comprising any one, a combination or all of the following: at least partially decellularizing a collagenous tissue; homogenizing the collagenous tissue; separating at least a portion of collagen fibers from the collagenous tissue; exposing the collagen fibers to an acidic solution before or after the separating; and forming at least one of a suture, a woven structure, a knitted structure, or a bioprosthetic device with the collagen fibers.
Claims14
A method of manufacturing collagen fibers, the method comprising:
- at least partially decellularizing a collagenous tissue;
- homogenizing the decellularized collagenous tissue to provide a homogenized suspension;
- incubating the homogenized suspension at a temperature of at least about 4° C. for a period of time from about 1 hour to about 24 hours;
- separating at least a portion of collagen fibers from the homogenized suspension after incubating;
- exposing the portion of collagen fibers to an acidic solution before or after the separating;
- exposing the portion of collagen fibers to a salt or a salt solution after exposing the portion of collagen fibers to the acidic solution;
- precipitating the portion of collagen fibers in a fibrous form after exposing the portion of collagen fibers to the salt or salt solution;
- and
- forming at least one of a suture, a woven structure, a knitted structure, or a bioprosthetic device with the precipitated collagen fibers.
6 more elements
Dependencies are inferred from the claim text.