NIR-II emissive luminogens
AssigneesThe Hong Kong University of Science and Technology, Hkust Shenzhen Research Institute
InventorsBenzhong Tang, Pengfei Zhang, Jen-Shyang Ni
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Abstract
Small molecule compounds having aggregation-induced emission (AIE) characteristics include donor-acceptor (D-A) structural NIR fluorophores based on 1,3-bis(dicyanomethylene)indan (BDCI), a strong and steric electron-deficient acceptor. A twisted quasi-double bond (TQDB) links each electron donor with the acceptor. The compounds can be used as NIR-II fluorescent dyes for in vivo imaging. The compounds can conjugate with bioactive molecules, such as peptides, sugars, aptamers and antibodies, to provide specific and active NIR-II fluorescent probes. The compounds can serve as active NIR-II fluorescent probes in many applications, such as, cancer cell-targeted imaging, accurate diagnosis of disease, and image-guided phototherapy.
Claims18
A compound having a backbone structural formula as follows:
- wherein each of R1 and R2 is independently selected from the group consisting of
- wherein each of R3, R4, R5, and R6 is independently selected from the group consisting of H, F, Cl, Br, I, alkyl, unsaturated alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, carboxyl group, amino group, sulfonic group, alkylthio, and alkoxy group;
- wherein R7 is selected from the group consisting of H, F, Cl, Br, I, alkyl, unsaturated alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, carboxyl group, amino group, sulfonic group, alkylthio, and alkoxy group;
- and
- n is an integer selected from 1, 2, 3, 4, and 5.
A compound having a structural formula as follows:
Dependencies are inferred from the claim text.