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US 12,023,375 B2Granted
Methods and compositions for activation of innate immune responses through RIG-I like receptor signaling
AssigneeUniversity of Washington
InventorsMichael J. Gale, Jr., Gretja Schnell, Yueh-Ming Loo
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Abstract
Compositions and methods are provided that enable activation of innate immune responses through RIG-I like receptor signaling. The compositions and methods incorporate synthetic nucleic acid pathogen associated molecular patterns (PAMPs) that comprise elements initially characterized in, and derived from, the hepatitis C virus genome.
Claims17
A pharmaceutical composition, wherein the pharmaceutical composition comprises:
- an isolated nucleic acid molecule comprising the sequence of SEQ ID NO:
- 1;
- and
- a carrier, wherein the carrier comprises a nanoparticle.
1 more element
Dependencies are inferred from the claim text.