Glyco-engineered immunization antigens
AssigneeExpres2ion Biotechnologies ApS
InventorsStine Broch Clemmensen, Teit Max Moscote Søgaard, Willem Adriaan De Jongh
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Abstract
Disclosed are immunization antigens that have been glyco-engineered to include non-native glycosylation patterns with a view to enhance their properties as antigens for use in such areas as vaccination and antibody production. Also disclosed are to means and methods for producing the glycomodified antigens as well of methods and uses of the glycomodified antigens.
Claims16
A genetically modified non-plant eukaryotic cell comprising at least one heterologous polynucleotide sequence encoding a heterologous α1,3-fucosyltransferase, wherein the cell is capable of producing N-glycosylated polypeptide or protein carrying α1,3-fucosyl groups, and wherein the cell exhibits reduced or abolished function of at least one α1,6-fucosyltransferase encoding gene.
Dependencies are inferred from the claim text.