Therapeutic compositions and methods of use for treating cancer
AssigneeAgalimmune Limited
InventorsUri Galili, Stephen Shaw, Michael Westby
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Abstract
The present invention relates to compositions and methods for treating cancer. More specifically, the present invention relates to compositions of engineered oncolytic viruses for administration to a subject with cancer that specifically lyse tumor cells and actively target tumor cells and cell debris to antigen presenting cells, in order to generate anti-tumor immunity.
Claims12
A method of inducing an immune response in an individual suffering from a tumor which comprises the steps of
- i) expressing an endogenous enzyme delivered by an oncolytic virus comprising a nucleic acid encoding an alpha 1,3-galactosyltransferase enzyme in at least one cancer cell of the individual to modify cell membrane glycosylation;
- and
- ii) inducing lysis of the at least one cancer cell resulting from administration of the oncolytic virus, wherein the administration is by direct injection into the tumor.
A method of inducing a protective anti-tumor immune response in an individual suffering from a tumor comprising administering to the individual a therapeutically effective amount of an oncolytic virus comprising a nucleic acid encoding an alpha 1,3-galactosyltransferase enzyme, wherein the administering is by direct injection into the tumor.
Dependencies are inferred from the claim text.