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US 12,023,360 B2Granted
Composition and methods of screening
AssigneeOptibiotix Limited
InventorsStephen Patrick O'Hara, Robert Rastall
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Abstract
The present invention relates to a symbiotic composition comprising a probiotic bacterial strain and a prebiotic growth medium which is specific to the growth of the probiotic bacterial strain, wherein the bacterial strain is capable of producing the same growth medium by reverse enzyme reaction. The present invention also relates to methods of producing and screening for such compositions.
Claims15
A synbiotic composition comprising:
- a Lactobacilli probiotic strain comprising a β-galactosidase enzyme producing a β1-4 linked galacto-oligosaccharide (GOS) through a reverse (3-galactosidase enzyme reaction;
- and
- a prebiotic growth medium comprising β1-4 linked GOS produced by the Lactobacilli probiotic strain through the reverse β-galactosidase enzyme reaction, wherein the Lactobacilli probiotic strain comprises a strain selected from Lactobacillus fermentum ATCC 11976 or Lactobacillus fermentum NCIMB 30226.
A method of producing a synbiotic composition comprising:
- selecting a Lactobacilli probiotic strain comprising a β-galactosidase enzyme producing a β1-4 linked galacto-oligosaccharide (GOS) through a reverse β-galactosidase enzyme reaction, the Lactobacilli probiotic strain producing a prebiotic growth medium comprising the β1-4 linked GOS;
- establishing a concentration of the pre biotic growth medium to provide growth selectivity of the desired quantity of the pro biotic bacterial strain;
- and
- combining the bacterial strain with the established concentration of growth medium to form the synbiotic composition, wherein the Lactobacilli probiotic strain comprises a strain selected from Lactobacillus fermentum ATCC 11976 or Lactobacillus fermentum NCIMB 30226.
1 more element
Dependencies are inferred from the claim text.