Engineered DNA polymerase variants
AssigneeCodexis, Inc.
InventorsMathew G. Miller, Vesna Mitchell, Jovana Nazor, Donald S. Baskerville, Nikki Dellas, David Elgart, Jonathan Vroom, Sandy M. Gomes, Nandhitha Subramanian, Ericka Bermudez
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Abstract
The present invention provides engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The invention also provides methods for use of the compositions comprising the engineered DNA polymerase polypeptides for diagnostic and other purposes.
Claims14
A polynucleotide comprising a polynucleotide sequence encoding an engineered DNA polymerase comprising a polypeptide sequence having at least 85% or more sequence identity to the reference sequence of SEQ ID NO:
- 6, wherein the polypeptide sequence comprises at least a substitution at amino acid position 515, wherein the amino acid positions are numbered with reference to SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.