Block-copolymers for the delivery of active agents
AssigneeJulius-Maximilians-UniversitäT WüRzburg
InventorsRobert Luxenhofer, Michael Lübtow
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Abstract
Provided is an (A)-(B)-(A) triblock copolymer comprising two hydrophilic polymer blocks (A) as further defined herein, and a polymer block (B), said polymer block (B) comprising at least one type of repeating unit of the following formula (I) wherein R1 is an aliphatic hydrocarbon group which is optionally substituted with one or more of —OR5, —SR5, —NR6R7, —(NR6R7R8)+, —CONR6R7, —C(O)OR9 and —C(O)R10, wherein R5 to R10 are independently selected from H, aliphatic and aromatic residues, and wherein R1 is selected such that the polymer block (B) is more hydrophobic than the polymer block (A); and compositions, such as pharmaceutical compositions, formed with the block copolymer.
Claims19
An (A)-(B)-(A) triblock copolymer comprising
- two hydrophilic polymer blocks (A), wherein a structure of the polymer blocks (A) is indicated independently for each of the two polymer blocks, by
- the following formula (IIa)
- wherein R2 is methyl or ethyl;
- and
- m is from 20 to 50;
- and
- a polymer block (B), wherein a structure of the polymer block (B) is indicated by the following formula (Ia)
- wherein R1 is a C3-C9 alkyl group and n is from 10 to 50;
- wherein the ratio of repeating units contained in polymer blocks (A) to repeating units contained in polymer block (B), in terms of the numbers of repeating units, ranges from 7:1 to 2:1.
Dependencies are inferred from the claim text.