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US 12,018,097 B2Granted
Non-chromatographic purification of macrocyclic peptides by a resin catch and release
AssigneeBristol-Myers Squibb Company
InventorsGardner S. Creech, Mahboubeh Kheirabadi, Martin D. Eastgate, David S. Nirschl, Percy H Carter
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Abstract
The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis. The synthesized peptide is capped with an alkyne-functionalized or azide-functionalized compound of formula (I): prior to cleavage of the peptide from the solid phase support.
Claims2
A compound of formula (I)
- wherein
- X is a bond, —O—, —C(O)—, —OC(O)—, —NH—, —N(C1-6alkyl)-, —N(aryl)-, —NH—C(O)—, —N(C1-6alkyl)C(O)—, or —N(aryl)C(O)—;
- and
- R1 is
- wherein R2 and R3 are each independently H, halo, C1-6alkyl, or OC1-6alkyl;
- Z is C1-6alk or —O—C1-6alk-;
- and
- Y is a bond or arylene.
5 more elements
Dependencies are inferred from the claim text.