Estrogen receptor-modulating compounds

A compound according to formula I′

• wherein:
• B is carbon;
• D is carbon;
• A is a fused ring system selected from the group consisting of:
• each Re is independently selected from hydrogen, halogen, OH, O(CO)R, O(CO)NR1R2, OPO3, OSO3, and O(SO2)NR1R2,
• R is C1-C6 alkyl or aryl;
• R1 and R2 are each independently hydrogen or C1-C6 alkyl;
• each R3 is hydrogen, C1-C12 acyl;
• C1-C12 acyloxy;
• each R4 is independently hydrogen, C1-C3 alkyl, fluorine or chlorine;
• each Rh is independently selected from hydrogen or CH3;
• Rg is hydrogen, C1-C3 alkyl, C1-C3 fluoroalkyl, CN, fluorine, chlorine or bromine;
• each Ra is independently selected from:
• H, C1-C3 alkyl, C1-C3 fluoroalkyl, phenyl (optionally substituted with 1-3 groups selected from fluorine, chlorine, C1-C3 alkyl, CN, OC1-C3 alkyl, OH), OH, OC1-3alkyl, CN, fluorine, chlorine, O(CO)R, O(CO)NR1R2, OPO3, OSO3, and O(SO2)NR1R2;
• X is O, S, CH2, NH or a bond when B is carbon, or CH2 or a bond when B is nitrogen;
• Y and Z are each independently selected from CRf or N;
• U and V are each independently selected from CRa or N;
• each Rf is independently H, C1-C3 alkyl, OC1-C3 alkyl, fluorine or chlorine;
• and
• W is —CHR′-CHR′—NH—C1-C4alkyl, —CHR′—CHR′—NH—C1-C4fluoroalkyl, —CHR′—CHR′—
• NH—C3-C6cycloalkyl, —CHR′-CHR′—NH—C1-C4alkyl-C3-C6cycloalkyl,
• wherein each R′ is independently H or C1-C3alkyl;
• or a pharmaceutically acceptable salt thereof.