Method for manufacturing diarylmethane compound
AssigneeTokuyama Corporation
InventorMasahiko Seki
Life of this patent
Estimating the term…
Abstract
An object is to provide a method for producing a compound which is useful as a synthetic intermediate for an active pharmaceutical ingredient of an antidiabetic drug or the like in an industrially inexpensive and efficient manner, and the present invention can achieve the object by reducing a compound (2) represented by the following formula (2): wherein R1, Ar, n and X are as mentioned herein in the presence of a titanium compound by using a reducing agent to produce a compound (1) represented by the following formula (1): wherein R1, Ar and n are the same as defined above.
Claims10
A method for producing a compound (1A) represented by the following formula (1A):
- the method comprising the following steps (a) and (b):
- (a) a step of providing a compound (2-1A) represented by the following formula (2-1A):
- and
- (b) a step of reducing the compound (2-1A) in the presence of TiCl4 by using an alkali metal borohydride salt to produce the compound (1A).
A method for producing a compound (1A) represented by the following formula (1A):
- the method comprising the following steps (a) and (b):
- (a) a step of providing a compound (2-1A) represented by the following formula (2-1A):
- and
- (b) a step of reducing the compound (2-1A) in the presence of a titanium compound by using an alkali metal borohydride salt to produce the compound (1A),
- wherein:
- the step (a) comprises a step of reacting a compound (4A) represented by the following formula (4A):
- with a compound (5) represented by the following formula (5):
- in the presence of a titanium compound to produce the compound (2-1A).
Dependencies are inferred from the claim text.