Compounds for modulating mitochondrial function

A method for treating a neurodegenerative disorder in a subject, wherein the neurodegenerative disorder is Huntington's disease, and wherein the method comprises administering to the subject a therapeutically effective amount of a compound of Formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• X is absent or selected from the group consisting of CH2 and C(O);
• R1 is selected from the group consisting of H, OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino;
• R2 is selected from the group consisting of H and C1-6 alkyl;
• R3 is selected from the group consisting of H, C1-6 alkyl, —C(O)(C1-3 alkyl), and —C(O)O(C1-3 alkyl);
• R4 is selected from the group consisting of C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, and 5-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 independently selected R5 groups;
• and
• R5 is selected from the group consisting of OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino.