Surgical repair graft
AssigneeTELA Bio, Inc.
InventorE. Skott Greenhalgh
Life of this patent
Estimating the term…
Abstract
The apparatuses and methods described herein relates generally to the field of active agent (drug) release from surgical grafts useful for soft tissue reconstruction, regeneration, or repair. More particularly, described herein are surgical grafts for soft tissue repair that include an active agent that is released over time while advantageously matching the biomechanical properties of tissue during healing and recovery.
Claims19
A method for controlled release of an active agent from a surgical repair graft comprising:
- exposing the surgical repair graft having one biotextile layer or a plurality of stacked biotextile layers and a bioabsorbable carrier matrix attached to at least one of the one or plurality of stacked biotextile layers to an aqueous fluid, the carrier matrix comprising the active agent, wherein the bioabsorbable carrier matrix comprises particles each having non-concentric internally aqueous chambers, wherein the particles are attached to the bioabsorbable carrier matrix at discrete attachments sites as islands that are spaced apart from each other to provide axial compliance to the surgical repair graft during bending;
- and
- degrading the carrier matrix over time by the aqueous fluid to thereby release the active agent from the carrier matrix.
A method for controlled release of an active agent from a surgical repair graft comprising:
- exposing the surgical repair graft having one biotextile layer or a plurality of stacked biotextile layers and a bioabsorbable carrier matrix attached to at least one of the one or plurality of stacked biotextile layers to an aqueous fluid, the carrier matrix comprising the active agent;
- and
- degrading the carrier matrix over time by the aqueous fluid to thereby release the active agent from the carrier matrix,
- wherein the bioabsorbable carrier matrix comprises particles including multivesicular liposomes having non-concentric internally aqueous chambers, wherein the particles are attached to the bioabsorbable carrier matrix at discrete attachments sites as islands that are spaced apart from each other to provide axial compliance to the surgical repair graft during bending.
A method for controlled release of an active agent from a surgical repair graft comprising:
- exposing the surgical repair graft having one biotextile layer or a plurality of stacked biotextile layers and a bioabsorbable carrier matrix attached to at least one of the one or plurality of stacked biotextile layers to an aqueous fluid, the carrier matrix comprising the active agent;
- and
- degrading the carrier matrix over time by the aqueous fluid to thereby release the active agent from the carrier matrix,
- wherein the bioabsorbable carrier matrix comprises a plurality of particles each having a plurality non-concentric internally aqueous chambers surrounded by lipid membranes, one or more of the internally aqueous chambers and the lipid membranes containing the active agent, wherein the particles are attached to the bioabsorbable carrier matrix at discrete attachments sites as islands that are spaced apart from each other to provide axial compliance to the surgical repair graft during bending.
Dependencies are inferred from the claim text.