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US 12,016,938 B2Granted
Pulp regeneration compositions and methods of forming and using the same
AssigneesTrustees of Tufts College, The Brigham and Women's Hospital, Inc.
InventorsPamela C. Yelick, Ali Khademhosseini
Life of this patent
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Abstract
A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel.
Claims21
A three-dimensional biomimetic model comprising:
- a tissue regenerative composition comprising
- a material at least partly obtained from an extracted tooth, and
- a light-activated hydrogel encapsulating the material;
- a biomimetic enamel organ layer, and
- a biomimetic pulp organ.
2 more elements
A method of forming a three-dimensional biometric model, the method comprising:
- forming a biomimetic enamel organ layer from a first material at least partly obtained from an extracted tooth, the first material being encapsulated in a light-activated hydrogel;
- and
- forming a biomimetic pulp organ from a second material at least partly obtained from an extracted tooth, the second material being encapsulated in the light-activated hydrogel.
Dependencies are inferred from the claim text.