Tissue catalyzed growth of polymer as epithelial linings for therapy
AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
InventorsRobert S. Langer, Carlo Giovanni Traverso, Junwei Li, Thomas Wang, Ameya R. Kirtane, Yunhua Shi
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Abstract
The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.
Claims15
A method of forming a dopamine polymer on a surface of a tissue in a subject in need thereof, the method comprising administering to the subject a composition comprising a plurality of molecules of dopamine, or a salt thereof, and at least a minimum amount of an oxygen source to polymerize the dopamine on the surface of the tissue, wherein the administering step delivers the plurality of molecules of dopamine, or a salt thereof and the oxygen source to the tissue of the subject, allowing the oxygen source to contact a catalyst in the tissue of the subject, and wherein the oxygen source reacts with the catalyst in the tissue to release oxygen from the oxygen source, and wherein the oxygen released from the oxygen source polymerizes the plurality of molecules of dopamine, or a salt thereof on the surface of the tissue, thereby forming said dopamine polymer on the surface of said tissue;
- wherein:
- the oxygen source is hydrogen peroxide or urea hydrogen peroxidalk;
- and the catalyst present in the tissue is catalase or peroxidase.
Dependencies are inferred from the claim text.