Methods and reagents for modulating macrophage phenotype
AssigneeNew York University
InventorsDafna Bar-Sagi, Jane Cullis, Craig Ramirez
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Abstract
The present invention is directed to methods of inducing a phenotypic change in a population of monocytes and/or macrophages. The method includes administering to the population of monocytes and/or macrophages, a macrophage stimulating agent coupled to a carrier molecule, wherein the carrier molecule facilitates macropinocytic uptake of the agent by monocytes and macrophages in the population and is defective in neonatal Fc receptor binding, wherein the administering induces a phenotypic change in the monocytes and macrophages in the population.
Claims19
A method of treating a tumor in a subject comprising:
- selecting a subject having a tumor and
- administering to the selected subject an anti-tumor agent coupled to a carrier molecule selected from (i) a modified or variant human albumin protein or fragment thereof, and (ii) a modified or variant human immunoglobulin G protein or fragment thereof, wherein the carrier molecule is defective in neonatal Fc receptor (FcRn) binding, wherein said anti-tumor agent and carrier molecule are taken up via macropinocytosis by monocytes and/or macrophages within the tumor microenvironment, thereby activating the monocytes and/or macrophages to have an anti-tumor immune response.
A method of treating a tumor in a subject comprising:
- selecting a subject having a tumor characterized by tumor cells expressing FcRn;
- and
- administering to the selected subject an anti-tumor agent coupled to a carrier molecule selected from (i) a modified or variant human albumin protein or fragment thereof and (ii) a modified or variant human immunoglobulin G protein or fragment thereof, wherein the carrier molecule is defective in neonatal Fc receptor (FcRn) binding, wherein said anti-tumor agent and carrier molecule are taken up by the tumor cells expressing FcRn to cause tumor cell death.
Dependencies are inferred from the claim text.