Insect toxin delivery mediated by a densovirus coat protein
AssigneesUniversity of Florida Research Foundation, Inc., Iowa State University Research Foundation, Inc.
InventorsBryony C. Bonning, Mariah Kemmerer
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Abstract
A coat protein of Junonia coenia densovirus (JcDNV) is used to deliver attached peptide insect toxin across the gut epithelium of a fall armyworm, Spodoptera frugiperda. A fusion protein comprising VP4 attached to an insect toxin via a peptide linker is developed. A composition comprising a JcDNV coat protein attached to an insect toxin via a peptide linker can be used for insect pest control.
Claims10
A recombinant DNA comprising a nucleic acid sequence encoding a fusion protein, wherein the fusion protein comprises a carrier protein attached to an insect toxin via a peptide linker, wherein the carrier protein is a Junonia coenia densovirus (JcDNV) coat protein.
Dependencies are inferred from the claim text.