Animal models, screening methods, and treatment methods for intraocular diseases or disorders
AssigneeSmilebiotek Zhuhai Limited
InventorsYan Zhang, Lai Wei, Hui Ouyang
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Abstract
Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
Claims20
A method comprising:
- (i) identifying, or having identified, a subject as being infected with a microorganism in the intraocular space, wherein the subject has age-related macular degeneration (AMD);
- and
- (ii) administering to the subject a therapeutically effective amount of an active compound selected from one of compounds (1)-(8) or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the active compound or pharmaceutically acceptable salt thereof, wherein compounds (1)-(8) have the following chemical structures:
- wherein the therapeutically effective amount is an amount effective in killing or inhibiting the growth of the microorganism in the intraocular space.
A method for ameliorating age-related macular degeneration (AMD) in a subject in need thereof, comprising:
- (i) identifying, or having identified, the subject as being infected with a microorganism in the intraocular space, wherein the microorganism comprises Bacillus megaterium;
- and
- (ii) administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising an active compound selected from compound (6) or a pharmaceutically acceptable salt thereof, wherein compound (6) is:
A method for ameliorating age-related macular degeneration (AMD) in a subject infected with a microorganism in the intraocular space, the method comprising killing or inhibiting the growth of the microorganism in the intraocular space by administering to the subject an effective amount of a pharmaceutical composition comprising an active compound selected from compound (6), wherein the microorganism comprises Bacillus megaterium, and wherein compound (6) is:
Dependencies are inferred from the claim text.