US 12,013,066 B1Granted

Methods and systems for reversibly consummating fluidic connections

AssigneeTrisk Bio Ltd.

InventorsAdam Luke Hiles, Gergo Bohner, Ryan Olf, Samuel Isidor Jones, Thomas Felix Martin Cummings, Gabor Pap, Spencer Ryan Wilson, Aaron Garden Cantrell, Michael Anthony Disimoni Stone, Matthew Edwin Page

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Abstract

Provided herein is a method for sterile fluid transfer. A first array of conduits may be disposed in a first compartment having a planar face with an array of cavities, each containing a cannular protrusion fluidly connected to a conduit. A second array of conduits may be disposed in a second compartment having its own planar face with an array of surface cannular protrusions, each fluidly connected to a conduit in the second array. The method may include sterilizing the lumens of each conduit-protrusion pair; snugly juxtaposing the two planar faces to form an array of steam-tight chambers; introducing a sterilizing gas into the chambers; expelling the sterilizing gas from the chambers; moving each cannular protrusion towards its facing surface protrusion to reversibly form a fluid connection therebetween, while the chamber remains externally sealed, and transferring a fluid across at least one fluidic connection.

Claims10

Dependent claims

A system, the system comprising a first and second conduit, the first and second conduit being at least partially disposed in a first compartment and a second compartment, respectively, wherein:

the first compartment comprises a block and a surface perforation, the perforation opening into a cavity in the block;
the cavity houses an intracavitary cannular protrusion;
the intracavitary cannular protrusion is fluidly connected to the first conduit;
the second compartment comprises a surface cannular protrusion protruding therefrom;
the surface cannular protrusion is fluidly connected to the second conduit;
the second compartment is configured to be pressed against the first compartment, so as to form a steam-tight chamber partially bounded by the cavity, wherein:
the chamber houses the intracavitary cannular protrusion and the surface cannular protrusion;
and
in a first configuration, the intracavitary cannular protrusion and the surface cannular protrusion axially align with one another without contacting one another,
and the intracavitary cannular protrusion and the surface cannular protrusion are each configured to automatically shut off liquid flow therethrough;
the chamber is at least partially surrounded by a cooling channel connected to a liquid channel;
the system comprises a waterproof boundary between the chamber and the cooling channel;
the chamber comprises a steam inlet opening, wherein the steam inlet opening is connected to a steam channel that traverses the cooling channel;
and
in a second configuration, the intracavitary cannular protrusion and the surface cannular protrusion mate with one another, thereby forming a fluid-tight connection;
and the system is configured to transition from the first configuration to the second configuration in response to a linear force being exerted on the intracavitary cannular protrusion.

13 more elements

A method for sterile fluid transfer between a first conduit and a second conduit, the method comprising:

juxtaposing a first compartment to a second compartment, wherein:
the first compartment comprises a block, the block having a first planar face, the first planar face comprising an opening, the opening leading to a cavity, the cavity located within the block;
a first cannular protrusion is disposed in the cavity;
the cavity is at least partially surrounded by a cooling channel connected to a liquid channel, wherein the chamber is fluidly insulated from the cooling channel;
the first cannular protrusion is fluidically connected to the first conduit;
the second compartment comprises a second planar face, the second planar face comprising a second cannular protrusion, wherein the second cannular protrusion protrudes from the second planar face;
the second cannular protrusion is fluidically connected to the second conduit;
and
when the planar faces of the first and second compartments are juxtaposed:
the second planar face presses against the opening to form an airtight chamber, wherein the chamber houses the first and second cannular protrusions and is partially bounded by the cavity;
and
the first and second cannular protrusions axially align without initially contacting one another, and the first and second cannular protrusions do not initially allow liquid flow therethrough;
introducing a heated gas into the chamber via a gas channel that traverses the cooling channel;
removing the gas;
introducing a liquid into the cooling channel;
exerting a linear force on the first cannular protrusion, thereby moving the first cannular protrusion towards the second cannular protrusion, mating the first and second cannular protrusions, and forming a fluidic connection with the second cannular protrusion;
and
moving a fluid between lumens of the first and second conduits.

15 more elements

Dependencies are inferred from the claim text.

Facts

Application: 18/386,716Filed 3 Nov 2023
Granted: 18 Jun 2024
Term ends: Not estimatedThe source records don’t support an estimate.

Classification17 codes

F16L 37/30
With fluid cut-off means: with fluid cut-off means in each of two pipe-end fittings
A61M 39/18
Having provision for disinfection or sterilisation: methods or apparatus for making the connection under sterile conditions, i.e. sterile docking
F16L 29/007
Joints with fluid cut-off means: joints with cut-off devices controlled separately
F16L 37/56
Couplings of the quick-acting type: for double-walled or multi-channel pipes or pipe assemblies