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US 12,012,390 B2Granted
Flavone compounds for the treatment and prophylaxis of hepatitis B virus disease
AssigneeHoffmann-La Roche Inc.
InventorsSong Feng, Chungen Liang, Yongfu Liu, Hong Shen, Xuefei Tan, Jun Wu, Dongdong Chen, Chao Li, Li Wang
Life of this patent
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Abstract
The present invention provides flavone derivatives having the general formula (I) which are useful for the treatment of Hepatitis B Virus infection (HBV). The compounds act as cccDNA (covalently closed circular DMA) inhibitors.
Claims19
A compound of formula (I)
- wherein:
- W is O or S;
- A1 is CH or CR4;
- A2 is CH or CR4;
- A3 is CH or CR4;
- A4 is N, CH or CR4;
- A5 is N, CH or CR4;
- A6 is CH;
- A7 is N or CH;
- R1 is halogen, C1-6alkyl or C3-7cycloalkyl;
- R2 is H, OH, halogen, C1-6alkoxy, haloC1-6alkoxy or phenylC1-6alkoxy;
- R3 is carboxy or C1-6alkoxycarbonyl;
- R4 is halogen, OH, CN, C1-6alkyl, C3-7cycloalkyl, C1-6alkoxy, oxopyrrolidinyl, morpholinyl or haloC1-6alkyl;
- G1 is C1-6alkylenyl, hydroxyC1-6alkylenyl or C3-7cycloalkylC1-6alkylenyl;
- and
- G2 is C1-6alkylenyl, C3-7cycloalkylenyl or phenylene;
- or a pharmaceutically acceptable salt, or enantiomer, or diastereomer thereof.
14 more elements
Dependencies are inferred from the claim text.