Liquid delivery composition
AssigneeCosmo Technologies Limited
InventorsFranca Ferrari, Cristina Bonferoni, Giuseppina Sandri, Luigi Maria Longo, Cristina Macelloni, Silvia Rossi
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Abstract
The invention provides a composition for use as a delivery vehicle comprising at least one thermo-responsive polymer (polymer A) and at least one ion-sensitive polymer (polymer B) in a liquid formulation. Polymer A is preferably a polyoxyethylene-polyoxypropylene block copolymer or a cellulose derivative. Polymer B a polysaccharide. The composition can include an active substance for delivery or can be used as a delivery vehicle for a substance added at the time of administration such as mesenchymal stem cells.
Claims11
A composition for use as a delivery vehicle comprising at least one thermo-responsive polymer, at least one ion-sensitive polymer, and at least one bio-adhesive polymer in a liquid formulation, wherein the at least one thermo-responsive polymer comprises 0.3-25% (w/w) poloxamer 407, the at least one ion-sensitive polymer comprises 0.01-2.0% (w/w) sodium alginate, and the at least one bio-adhesive polymer comprises 0.01-2.0% (w/w) sodium carboxymethylcellulose, wherein the composition comprises at least one active substance for delivery, wherein the at least one active substance comprises:
- monoclonal antibodies, anti-acids, adrenergic drugs, anti-adrenergic drugs, dyes, steroidal and non-steroidal anti-inflammatory drugs, nasal antihistamines, nasal decongestants, anti-neoplastics, antimicrobics, antibiotics, antifungal drugs, genitourinary tract agents, vaginal agents, vaginal antifungal, vaginal antibiotics, oral cavity disinfectants or oral cavity antibiotics, wound healing drugs, haemostatics, anaesthetics, or a mixture thereof;
- wherein the composition is formulated such that an active substance can be added at the time of administration.
Dependencies are inferred from the claim text.