Methods of metabolic regulation of mitochondria for treating neural injury and neurological disorders
AssigneeThe USA, as represented by the Secretary, Dept. of Health and Human Services
InventorsWei Li, Tantai Zhao, Jingxing Ou
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Abstract
Methods are disclosed for treating and/or preventing a neurological condition, such as neural injury or neurological disorder, in a subject through metabolic regulation of mitochondria using compounds that are natural metabolites, metabolite analogs, or derivatives of natural metabolites to modulate biochemical pathways comprising succinate and/or succinate dehydrogenase, thereby reducing microglial cell and/or astrocyte activation. Compounds and related formulations are also provided to modulate the biochemical pathways comprising succinate and/or succinate dehydrogenase for reducing or inhibiting microglial cell and/or astrocyte activation.
Claims12
A method of inhibiting activation of microglial cells, comprising contacting the microglial cells with a compound that decreases the level of succinate in the cells, or that reduces the activity of succinate dehydrogenase, wherein the compound comprises dimethyl malonate (DMM), oxaloacetic acid, or octyl itaconate.
A method of preventing the activation of an astrocyte in a system comprising microglial cells and astrocytes, comprising introducing into the system a compound that decreases the level of succinate in the cells, or that reduces the activity of succinate dehydrogenase, wherein the compound comprises dimethyl malonate (DMM), oxaloacetic acid, or octyl itaconate.
Dependencies are inferred from the claim text.