# US 12,009,090 B2 · Liver cancer detection

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- Number: US 12,009,090 B2
- Document ID: US12009090B2
- Status: Granted
- Kind: B2
- Application number: 18/184,420
- Filed: 2023-03-15
- Published: 2023-11-16
- Granted: 2024-06-11
- Earliest claimed: 2019-11-12
- Assignees: Hepatiq, Inc.
- Applicants: Hepatiq, Inc.
- Inventors: Dipankar Ghosh; John Carl Hoefs
- Web page: https://patentgrep.com/patent/US12009090B2

## CPC

- G16H 30/20: for handling medical images, e.g. DICOM, HL7 or PACS
- G06T 7/0012: {Biomedical image inspection}
- G06T 7/20: Analysis of motion (motion estimation for coding, decoding, compressing or decompressing digital video signals H04N19/43, H04N19/51)
- G06T 7/62: of area, perimeter, diameter or volume
- G16H 10/60: for patient-specific data, e.g. for electronic patient records
- G16H 15/00: ICT specially adapted for medical reports, e.g. generation or transmission thereof
- G16H 30/40: for processing medical images, e.g. editing
- G16H 50/30: for calculating health indices; for individual health risk assessment
- G06T 2207/10016: Video; Image sequence
- G06T 2207/10108: Single photon emission computed tomography [SPECT]
- G06T 2207/20224: Image subtraction
- G06T 2207/30056: Liver; Hepatic
- G06T 2207/30096: Tumor; Lesion
- G16H 20/00: ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL

## Abstract

Methods and systems for determining a tumor volume from image data obtained from a functional scanner. The methods and systems can include identifying a portion within a region of interest corresponding to a liver that varies in intensity with its corresponding neighboring portion by a threshold. The method and systems can further include determining a volume of the portion without identifying a boundary of the portion. The portion can also be tracked over time. The image data can include a scan from a SPECT scanner.

## Claims

### Claim 1

A system for simultaneously determining for an organ, a tumor parameter and an organ function parameter, from image data obtained from a functional scanner, the system comprising one or more hardware processors configured to:
determine a region of interest corresponding to an organ from image data taken;
determine a shape within the region of interest that includes an entire volume of a suspected tumor mass;
determine a first volume of functional tissue within the shape based on a concentration of isotopes intensities;
determine a second volume of the suspected tumor mass based on the determined first volume;
determine an organ function parameter based on the determined region of interest; and
display a tumor parameter and the organ function parameter, wherein the tumor parameter includes the second volume of the suspected tumor mass.

### Claim 2 (depends on 1)

The system of claim 1, wherein the one or more hardware processors are further configured to determine a volume of the tumor without identifying a boundary of the tumor.

### Claim 3 (depends on 1)

The system of claim 1, wherein the shape comprises a 3D ellipsoid.

### Claim 4 (depends on 1)

The system of claim 1, wherein the shape comprises a 3D tubular shape.

### Claim 5 (depends on 1)

The system of claim 1, wherein the one or more hardware processors are further configured to determine that the shape corresponds to a blood vessel or a cyst.

### Claim 6 (depends on 1)

The system of claim 1, wherein the one or more hardware processors are further configured to pre-process the image data.

### Claim 7 (depends on 6)

The system of claim 6, wherein the pre-processing comprises at least one or more of: boosting resolution, sharpening, slicing, or dicing.

### Claim 8 (depends on 1)

The system of claim 1, wherein the second volume is determined without use of molecular cancer tagging agents.

### Claim 9 (depends on 1)

The system of claim 1, wherein the organ function parameter comprises Perfused Hepatic Mass (PHM), Hepatic Activity Index (HAI), Total Counts Ratio (TCR), Normalized Liver Volume (NLV), or Normalized Spleen Volume (NSV).

### Claim 10 (depends on 1)

The system of claim 1, wherein the one or more hardware processors are further configured to track a trend in organ function and tumor parameters.

### Claim 11

A method for simultaneously determining for an organ, a tumor parameter and an organ function parameter, from image data obtained from a functional scanner, the method comprising:
determining a region of interest corresponding to an organ from image data taken;
determining a shape within the region of interest that includes an entire volume of a suspected tumor mass;
determining a first volume of functional tissue within the shape based on a concentration of isotopes intensities;
determining a second volume of the suspected tumor mass based on the determined first volume;
determining an organ function parameter based on the determined region of interest; and
displaying a tumor parameter and the organ function parameter, wherein the tumor parameter includes the second volume of the suspected tumor mass.

### Claim 12 (depends on 11)

The method of claim 11, further comprising determining a volume of the tumor without identifying a boundary of the tumor.

### Claim 13 (depends on 11)

The method of claim 11, wherein the shape comprises a 3D ellipsoid.

### Claim 14 (depends on 11)

The method of claim 11, wherein the shape comprises a 3D tubular shape.

### Claim 15 (depends on 11)

The method of claim 11, further comprising determining that the shape corresponds to a blood vessel or a cyst.

### Claim 16 (depends on 11)

The method of claim 11, further comprising pre-processing the image data.

### Claim 17 (depends on 16)

The method of claim 16, wherein the pre-processing comprises at least one or more of: boosting resolution, sharpening, slicing, or dicing.

### Claim 18 (depends on 11)

The method of claim 11, wherein the second volume is determined without use of molecular cancer tagging agents.

### Claim 19 (depends on 11)

The method of claim 11, wherein the organ function parameter comprises Perfused Hepatic Mass (PHM), Hepatic Activity Index (HAI), Total Counts Ratio (TCR), Normalized Liver Volume (NLV), or Normalized Spleen Volume (NSV).

### Claim 20 (depends on 11)

The method of claim 11, further comprising determining a trend in organ function and tumor parameters.