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US 12,007,391 B2Granted
Means and methods for determining risk of type-1 diabetes by serum protein biomarkers
AssigneeTurun Yliopisto
InventorsRobert Moulder, Santosh Bhosale, David Goodlett, Harri Lähdesmäki, Olli Simell, Riitta Lahesmaa
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Abstract
The present invention relates to methods for predicting a risk of a subject for Type 1 diabetes (T1D) on the basis of expression levels of protein markers in a sample obtained from the subject. The present invention also relates to in vitro kits for use in said methods.
Claims12
A method of determining an individual at risk of and/or progression towards Type 1 Diabetes (T1D), the method comprising:
- a) determining a protein marker profile in a sample obtained from the individual, said profile comprising profilin-1 (PROF1) and filamin-A (FLNA),
- b) comparing the determined protein marker profile of PROF1 and FLNA of the individual with that of a corresponding control profile of PROF1 and FLNA in a control sample from a control individual or a pool of control individuals,
- c) responsive to the comparison, determining the risk of and/or progression towards T1D in the individual, wherein higher levels of PROF1 and FLNA in the sample obtained from the individual as compared to the levels of PROF1 and FLNA in the control sample indicates that the individual is at risk of and/or progression towards T1D, and
- d) providing a treatment or dietary change to the individual to correct the protein marker profile of the individual towards that of an unaffected individual.
1 more element
Dependencies are inferred from the claim text.