# US 12,007,338 B2 · In vitro sensor for analyzing in vitro flowing fluids > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,007,338 B2 - Document ID: US12007338B2 - Status: Granted - Kind: B2 - Application number: 17/468,298 - Filed: 2021-09-07 - Published: 2022-03-10 - Granted: 2024-06-11 - Earliest claimed: 2020-09-09 - Assignees: Know Labs, Inc. - Applicants: Know Labs, Inc. - Inventors: Phillip Bosua - Web page: https://patentgrep.com/patent/US12007338B2 ## CPC - G01N 22/00: Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more (G01N3/00 - G01N17/00, G01N24/00 take precedence) - G01N 33/487: of liquid biological material - G01S 13/02: Systems using reflection of radio waves, e.g. primary radar systems; Analogous systems - G01S 17/02: Systems using the reflection of electromagnetic waves other than radio waves (G01S17/66 takes precedence) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - G01S: RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES ## Abstract Apparatus, systems and methods of analyzing an in vitro flowing fluid using an in vitro sensor that operates using non-optical frequencies such as in the radio or microwave frequency bands of the electromagnetic spectrum. The in vitro sensor directs one or more signals that are in the radio or microwave frequency bands of the electromagnetic spectrum into an in vitro flowing fluid and detects one or more responses that result from transmission of the signal(s) into the in vitro flowing fluid. ## Claims ### Claim 1 An in vitro sensing system, comprising: an in vitro sensor that is positioned adjacent to an in vitro fluid passageway that contains an in vitro flowing fluid; and the in vitro sensor includes: at least one transmit antenna and at least one receive antenna, the at least one transmit antenna is positioned and arranged to transmit a signal into the in vitro flowing fluid in the in vitro fluid passageway, wherein the signal is in a radio or microwave frequency range of the electromagnetic spectrum, and the at least one receive antenna is positioned and arranged to detect a response resulting from transmission of the signal by the at least one transmit antenna into the in vitro flowing fluid, wherein the at least one transmit antenna consists of a strip of conductive material having at least one lateral dimension thereof greater than a thickness dimension thereof, the strip of conductive material of the at least one transmit antenna is disposed on a substrate, the at least one receive antenna consists of a strip of conductive material having at least one lateral dimension thereof greater than a thickness dimension thereof, the strip of conductive material of the at least one receive antenna is disposed on the substrate, the at least one transmit antenna and the at least one receive antenna are coplanar with one another, and a geometry of the at least one transmit antenna differs from a geometry of the at least one receive antenna. ### Claim 2 (depends on 1) The in vitro sensing system of claim 1, wherein the in vitro sensor further includes: a transmit circuit that is electrically connectable to the at least one transmit antenna, the transmit circuit is configured to generate the signal to be transmitted by the at least one transmit antenna; and a receive circuit that is electrically connectable to the at least one receive antenna, the receive circuit is configured to receive a response detected by the at least one receive antenna. ### Claim 3 (depends on 1) The in vitro sensing system of claim 1, wherein the radio or microwave frequency range is between about 10 kHz to about 100 GHz. ### Claim 4 (depends on 1) The in vitro sensing system of claim 1, wherein the in vitro flowing fluid comprises a liquid as a primary component. ### Claim 5 (depends on 1) The in vitro sensing system of claim 1, wherein the in vitro flowing fluid comprises a gas as a primary component. ### Claim 6 (depends on 1) The in vitro sensing system of claim 1, wherein the in vitro flowing fluid comprises a nonbodily fluid as a primary component. ### Claim 7 (depends on 1) The in vitro sensing system of claim 1, wherein the in vitro flowing fluid where the signal is transmitted into has laminar flow. ### Claim 8 (depends on 1) The in vitro sensing system of claim 1, wherein the in vitro sensor is located outside the in vitro fluid passageway, the at least one transmit antenna and the at least one receive antenna face the in vitro fluid passageway, and at least a portion of the in vitro fluid passageway facing the at least one transmit antenna and the at least one receive antenna is formed from a non-optically transparent material. ### Claim 9 (depends on 1) The in vitro sensing system of claim 1, wherein the in vitro sensor is located inside the in vitro fluid passageway and the in vitro sensor is at least partially immersed in the in vitro flowing fluid. ### Claim 10 An in vitro sensing system configured to sense an analyte in an in vitro flowing fluid, comprising: an in vitro sensor that is positioned adjacent to an in vitro fluid passageway that contains the in vitro flowing fluid with the analyte; and the in vitro sensor includes: at least one transmit element and at least one receive element, the at least one transmit element is positioned and arranged to transmit a signal into the in vitro flowing fluid in the in vitro fluid passageway, wherein the signal is in a radio or microwave frequency range of the electromagnetic spectrum that is between about 10 kHz to about 100 GHz, and the at least one receive element is positioned and arranged to detect a response resulting from transmission of the signal by the at least one transmit element into the in vitro flowing fluid, wherein the at least one transmit element consists of a strip of conductive material having at least one lateral dimension thereof greater than a thickness dimension thereof, the strip of conductive material of the at least one transmit element is disposed on a substrate, the at least one receive element consists of a strip of conductive material having at least one lateral dimension thereof greater than a thickness dimension thereof, the strip of conductive material of the at least one receive element is disposed on the substrate, the at least one transmit element and the at least one receive element are coplanar with one another, and a geometry of the at least one transmit element differs from a geometry of the at least one receive element. ### Claim 11 (depends on 10) The in vitro sensing system of claim 10, wherein the in vitro sensor further includes a transmit circuit that is electrically connectable to the at least one transmit element, the transmit circuit is configured to generate the signal to be transmitted by the at least one transmit element; and a receive circuit that is electrically connectable to the at least one receive element, the receive circuit is configured to receive a response detected by the at least one receive element. ### Claim 12 (depends on 10) The in vitro sensing system of claim 10, wherein the in vitro flowing fluid comprises a liquid as a primary component. ### Claim 13 (depends on 10) The in vitro sensing system of claim 10, wherein the in vitro flowing fluid comprises a gas as a primary component. ### Claim 14 (depends on 10) The in vitro sensing system of claim 10, wherein the in vitro flowing fluid comprises a non-bodily fluid as a primary component. ### Claim 15 (depends on 10) The in vitro sensing system of claim 10, wherein the in vitro flowing fluid where the signal is transmitted into has laminar flow. ### Claim 16 (depends on 10) The in vitro sensing system of claim 10, wherein the in vitro sensor is located outside the in vitro fluid passageway, the at least one transmit antenna and the at least one receive antenna face the in vitro fluid passageway, and at least a portion of the in vitro fluid passageway facing the at least one transmit antenna and the at least one receive antenna is formed from a non-optically transparent material. ### Claim 17 (depends on 10) The in vitro sensing system of claim 10, wherein the in vitro sensor is located inside the in vitro fluid passageway such that the in vitro sensor is at least partially immersed in the in vitro flowing fluid. ### Claim 18 (depends on 10) The in vitro sensing system of claim 10, wherein the analyte in the in vitro flowing fluid comprises cholesterol, blood glucose, blood alcohol, white blood cells, or luteinizing hormone. ### Claim 19 (depends on 2) The in vitro sensing system of claim 2, wherein the in vitro sensor further comprises a battery and the at least one transmit antenna, the transmit circuit, the at least one receive antenna, the receive circuit, and the battery are all disposed in a housing. ### Claim 20 (depends on 11) The in vitro sensing system of claim 11, wherein the in vitro sensor further comprises a battery and the at least one transmit element, the transmit circuit, the at least one receive element, the receive circuit, and the battery are all disposed in a housing.