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US 12,006,513 B2Granted
Methods for the long-term expansion of granulocyte-macrophage progenitors and applications thereof
AssigneeUniversity of Southern California
InventorsQi-Long Ying, Shi Yue
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Abstract
The disclosure provides methods for the long-term expansion of granulocyte-macrophage progenitors, the granulocyte-macrophage progenitors generated therefrom, and uses of the granulocyte-macrophage progenitors thereof.
Claims22
A method for the expansion of a population of granulocyte/macrophage progenitor cells (GMPs), comprising:
- culturing GMPs in a culture medium comprising:
- (i) a growth factor,
- (ii) a B-Raf kinase inhibitor, and
- (iii) a Wnt activator and/or a GSK-3 inhibitor,
- wherein the GMPs remain substantially morphologically unchanged after undergoing multiple cell passages and/or clonal expansion.
2 more elements
Dependencies are inferred from the claim text.