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US 12,006,364 B2Granted
Anti-CD100 antibodies and methods for using the same
AssigneeVaccinex, Inc.
InventorsErnest S. Smith, Terrence Lee Fisher
Life of this patent
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Abstract
Compositions and methods are provided for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers. In particular, anti-CD100 monoclonal antibodies have been developed to neutralize CD100.
Claims13
A method of neutralizing CD100 in an animal, comprising administering to the animal a composition comprising:
- a) an isolated antibody or antigen-binding fragment thereof that specifically binds to a semaphorin 4D (SEMA4D) receptor;
- and
- b) a pharmaceutically acceptable carrier,
- wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable region (VH) polypeptide comprising VH complementarity determining regions (CDR) VH-CDR1, VH-CDR2, and VH-CDR3 amino acid sequences comprising SEQ ID Nos:
- 6, 7, and 8, respectively, and a light chain variable region (VL) polypeptide comprising VL complementarity determining regions VL-CDR1, VL-CDR2, and VL-CDR3 amino acid sequences comprising SEQ ID Nos:
- 14, 15, and 16, respectively.
3 more elements
A method of treating an autoimmune disease or an inflammatory disease in an animal in need of treatment, comprising administering to said animal a composition comprising:
- a) an isolated antibody or antigen-binding fragment thereof that specifically binds to a semaphorin 4D (SEMA4D) receptor;
- and
- b) a pharmaceutically acceptable carrier;
- wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable region (VH) polypeptide comprising VH complementarity determining regions (CDR) VH-CDR1, VH-CDR2, and VH-CDR3 amino acid sequences comprising SEQ ID Nos:
- 6, 7, and 8, respectively, and a light chain variable region (VL) polypeptide comprising VL complementarity determining regions VL-CDR1, VL-CDR2, and VL-CDR3 amino acid sequences comprising SEQ ID Nos:
- 14, 15, and 16, respectively.
3 more elements
Dependencies are inferred from the claim text.